The National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) grant has been renewed for an additional five years with funding expected to total $ 30 million from the National Institute on Aging (NIA), within the National Institutes of the Health (NIH). NCRAD is led by Tatiana Foroud, PhD, Executive Associate Dean for Research Affairs at IU School of Medicine. As of 2018, NCRAD has been among the top five grants awarded to the IU School of Medicine.
The National Centralized Repository for Alzheimer’s Disease and Related Dementias serves as the primary resource for samples for all dementia studies funded by the NIA. Over the next five years, our recruitment efforts will focus on engaging diverse communities in order to obtain a wide range of samples of individuals who represent the diverse populations that make up our nation and our world. “
Tatiana Foroud, President of the Department of Medical and Molecular Genetics at the IU School of Medicine
NCRAD supports research into the causes, early detection and therapeutic development of Alzheimer’s disease and other dementias. The repository houses over one million biological samples, including DNA, plasma, brain tissue and cell lines. These samples help scientists conduct various research on Alzheimer’s disease and dementia, such as the development of blood biomarker tests, which are less expensive and invasive than other methods of early detection of dementia, such as PET scans. and the cerebrospinal fluid test.
Since its inception in 1990, NCRAD has distributed more than 300,000 samples to researchers around the world, leading to more than 600 publications in scientific journals. Scientists have banked samples for dozens of studies with the NCRAD, which also stores healthy control samples. With the latest expansion in 2018, the NCRAD program changed its name to include ‘Dementias Related’ to reflect the wide range of research activities it supports, added staff, and centralized samples at larger facilities. and recently remodeled in Indianapolis.
NCRAD is one of a range of research resources funded by the NIA as part of its ambitious goal of developing effective prevention strategies and treatments for Alzheimer’s disease and related dementias by 2025. The Burden of Alzheimer’s disease and related dementias in the United States is expected to reach 13.9 million people by 2060, which represents nearly 3.3% of the population.
“It has been amazing to watch NCRAD grow over the past few years, even during the COVID-19 pandemic,” said Foroud, who also leads the Grand Challenge at the IU Precision Health Initiative. The Precision Health Initiative is the first Grand Challenge funded by Indiana University, which has bold goals to prevent Alzheimer’s disease by analyzing the genetic, developmental, behavioral and environmental factors that shape an individual’s health. . “We are proud to work with researchers around the world to continue efforts to prevent and treat this dreaded disease. “